解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Aspergillus species are saprophytic molds causing life-threatening invasive fungal infections in the immunocompromised host. Innate immune recognition, in particular, the mechanisms of opsonization and complement activation, has been reported to be an integral part of the defense against fungi. We have shown that the ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00032-13
更新日期:2013-05-01 00:00:00
abstract::Brucella abortus is recognized by several Toll-like receptor (TLR)-associated pathways triggering proinflammatory responses that affect both the nature and intensity of the immune response. Previously, we demonstrated that B. abortus-mediated dendritic cell (DC) maturation and control of infection are dependent on the...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01356-12
更新日期:2013-05-01 00:00:00
abstract::Whooping cough results from infection of the respiratory tract with Bordetella pertussis, and the secreted adenylate cyclase toxin (ACT) is essential for the bacterium to establish infection. Despite extensive study of the mechanism of ACT cytotoxicity and its effects over a range of concentrations in vitro, ACT has n...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00110-13
更新日期:2013-05-01 00:00:00
abstract::Filarial infection is initiated by mosquito-derived third-stage larvae (L3) deposited on the skin that transit through the epidermis, which contains Langerhans cells (LC) and keratinocytes (KC), among other cells. This earliest interaction between L3 and the LC likely conditions the priming of the immune system to the...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01301-12
更新日期:2013-05-01 00:00:00
abstract::Nontypeable Haemophilus influenzae (NTHi) is a commensal microorganism of the human nasopharynx, and yet is also an opportunistic pathogen of the upper and lower respiratory tracts. Host microenvironments influence gene expression patterns, likely critical for NTHi persistence. The host sequesters iron as a mechanism ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01227-12
更新日期:2013-04-01 00:00:00
abstract::The expression of T cell differentiation markers is known to increase during Mycobacterium tuberculosis infection, and yet the biological role of such markers remains unclear. We examined the requirement of the T cell differentiation marker killer cell lectin-like receptor G1 (KLRG1) during M. tuberculosis infection u...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01199-12
更新日期:2013-04-01 00:00:00
abstract::Francisella tularensis is a facultative intracellular bacterial pathogen and the causative agent of tularemia. After infection of macrophages, the organism escapes from its phagosome and replicates to high density in the cytosol, but the bacterial factors required for these aspects of virulence are incompletely define...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00822-12
更新日期:2013-03-01 00:00:00
abstract::The fungus Cryptococcus neoformans has emerged as a major cause of meningoencephalitis worldwide. Host response to the fungus involves both innate and adaptive immunity, but fungal genes that modulate these processes are poorly understood. Previous studies demonstrated attenuated virulence of a mutant of a virulence-a...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00821-12
更新日期:2013-03-01 00:00:00
abstract::Schistosomiasis affects nearly 40 million women of reproductive age. Many of these women are infected while pregnant and lactating. Several studies have demonstrated transplacental trafficking of schistosome antigens; however, little is known regarding how these antigens affect the developing fetus and placenta. To ev...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01149-12
更新日期:2013-03-01 00:00:00
abstract::The efficacy of the innate immune system depends on its ability to mount an appropriate response to diverse infections and damaging agents. Key components of this system are pattern recognition receptors that detect pathogen-associated and damage-associated molecular patterns (PAMPs and DAMPs). Nlrp1b is a pattern rec...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01003-12
更新日期:2013-02-01 00:00:00
abstract::Mycobacterium avium subsp. paratuberculosis is the causative agent of Johne's disease in cattle. The complex, multifaceted interaction of M. avium subsp. paratuberculosis with its host includes dampening the ability of infected cells to respond to stimuli that promote M. avium subsp. paratuberculosis clearance. By dis...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00785-12
更新日期:2013-01-01 00:00:00
abstract::Streptococcus iniae causes systemic infection characterized by meningitis and sepsis. Here, we report a larval zebrafish model of S. iniae infection. Injection of wild-type S. iniae into the otic vesicle induced a lethal infection by 24 h postinfection. In contrast, an S. iniae mutant deficient in polysaccharide capsu...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00642-12
更新日期:2013-01-01 00:00:00
abstract::Merozoite surface protein 2 (MSP2) is an abundant glycosylphosphatidylinositol (GPI)-anchored protein of Plasmodium falciparum, which is a potential component of a malaria vaccine. As all forms of MSP2 can be categorized into two allelic families, a vaccine containing two representative forms of MSP2 may overcome the ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00665-12
更新日期:2012-12-01 00:00:00
abstract::Genetic factors that regulate the pathogenesis of pneumonia caused by the fungus Cryptococcus neoformans are poorly understood. Through a phenotypic strain survey we observed that inbred C3H/HeN mice develop a significantly greater lung fungal burden than mice of the resistant CBA/J strain 4 weeks following intratrach...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00417-12
更新日期:2012-12-01 00:00:00
abstract::FMS-like tyrosine kinase-3 ligand (Flt3L) is a dendritic cell (DC) growth and differentiation factor with potential in antitumor therapies and antibacterial immunization strategies. However, the effect of systemic Flt3L treatment on lung-protective immunity against bacterial infection is incompletely defined. Here, we...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00854-12
更新日期:2012-12-01 00:00:00
abstract::Vitamin D is an important regulator of the expression of antimicrobial peptides, and vitamin D deficiency is associated with respiratory infections. Regulating expression of antimicrobial peptides, such as the human cathelicidin antimicrobial peptide 18 (hCAP18)/LL-37, by vitamin D in bronchial epithelial cells requir...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.06224-11
更新日期:2012-12-01 00:00:00
abstract::Interleukin-1 receptor (IL1R)-associated kinase 4 (IRAK4) is a member of the IRAK family and has an important role in inducing the production of inflammatory mediators. This kinase is downstream of MyD88, an adaptor protein essential for Toll-like receptor (TLR) function. We investigated the role of this kinase in IRA...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00328-12
更新日期:2012-12-01 00:00:00
abstract::The Toll-like receptor 2 (TLR2)/TLR1 receptor complex responds to amyloid fibrils, a common component of biofilm material produced by members of the phyla Firmicutes, Bacteroidetes, and Proteobacteria. To determine whether this TLR2/TLR1 ligand stimulates inflammatory responses when bacteria enter intestinal tissue, w...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00911-12
更新日期:2012-12-01 00:00:00
abstract::Streptococcus agalactiae (group B Streptococcus or GBS) is a common colonizer of the gastrointestinal and genital tracts and an important cause of invasive infections in newborn infants and in adults with predisposing chronic conditions or advanced age. Attachment to epithelial surfaces at mucosal sites is a critical ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00699-12
更新日期:2012-11-01 00:00:00
abstract::In meningococcal septic shock, the dominant inducer of inflammation is lipopolysaccharide (LPS) in the outer membrane of Neisseria meningitidis, while interleukin-10 (IL-10) is the principal anti-inflammatory cytokine. We have used microarrays and Ingenuity Pathway Analysis to study the global effects of IL-10 on gene...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00386-12
更新日期:2012-11-01 00:00:00
abstract::Pathogenic Leptospira spp. are likely to encounter higher concentrations of reactive oxygen species induced by the host innate immune response. In this study, we characterized Leptospira interrogans catalase (KatE), the only annotated catalase found within pathogenic Leptospira species, by assessing its role in resist...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00466-12
更新日期:2012-11-01 00:00:00
abstract::Tuberculosis (TB) is a leading cause worldwide of human mortality attributable to a single infectious agent. Recent studies targeting candidate genes and "case-control" association have revealed numerous polymorphisms implicated in host susceptibility to TB. Here, we review current progress in the understanding of cau...
journal_title:Infection and immunity
pub_type: 杂志文章,评审
doi:10.1128/IAI.00443-12
更新日期:2012-10-01 00:00:00
abstract::We show in this study that toxin production in Clostridium difficile is altered in cells which can no longer form flagellar filaments. The impact of inactivation of fliC, CD0240, fliF, fliG, fliM, and flhB-fliR flagellar genes upon toxin levels in culture supernatants was assessed using cell-based cytotoxicity assay, ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00224-12
更新日期:2012-10-01 00:00:00
abstract::Neisseria meningitidis crosses the blood-brain barrier (BBB) following the activation of the β2-adrenergic receptor by the type IV pili (TFP). Two components of the type IV pili recruit the β2-adrenergic receptor, the major pilin PilE and the minor pilin PilV. Here, we report that a strain deleted of PilX, one of the ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00369-12
更新日期:2012-09-01 00:00:00
abstract::Clostridium perfringens type B causes enteritis and enterotoxemia in domestic animals. By definition, these bacteria must produce alpha toxin (CPA), beta toxin (CPB) and epsilon toxin (ETX) although most type B strains also produce perfringolysin O (PFO) and beta2 toxin (CPB2). A recently identified Agr-like quorum-se...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00438-12
更新日期:2012-09-01 00:00:00
abstract::Pathogenic species of the spotted fever group Rickettsia are subjected to repeated exposures to the host complement system through cyclic infections of mammalian and tick hosts. The serum complement machinery is a formidable obstacle for bacteria to overcome if they endeavor to endure this endozoonotic cycle. We have ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00349-12
更新日期:2012-08-01 00:00:00
abstract::Shiga toxin-producing Escherichia coli (STEC) is a food-borne pathogen with a low infectious dose that colonizes the colon in humans and can cause severe clinical manifestations such as hemolytic-uremic syndrome. The urease enzyme, encoded in the STEC chromosome, has been demonstrated to act as a virulence factor in o...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00210-12
更新日期:2012-08-01 00:00:00
abstract::Despite the autotransporter (AT) moniker, AT secretion appears to involve the function of periplasmic chaperones. We identified four periplasmic proteins that specifically bound to plasmid-encoded toxin (Pet), an AT produced by enteroaggregative Escherichia coli (EAEC). These proteins include the 17-kDa Skp chaperone ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00167-12
更新日期:2012-07-01 00:00:00
abstract::The C-terminal 19-kDa domain of merozoite surface protein 1 (MSP1₁₉) is the target of protective antibodies but alone is poorly immunogenic. Previously, using the Plasmodium yoelii murine model, we fused P. yoelii MSP1₁₉ (PyMSP1₁₉) with full-length P. yoelii merozoite surface protein 8 (MSP8). Upon immunization, the M...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00211-12
更新日期:2012-07-01 00:00:00
abstract::Among a number of laboratory strains of Listeria monocytogenes used in experimental infection, strain LO28 is highly capable of inducing robust beta interferon (IFN-β) production in infected macrophages. In this study, we investigated the molecular mechanism of the IFN-β-inducing ability of LO28 by comparing it with t...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.06162-11
更新日期:2012-07-01 00:00:00
abstract::An immunomodulatory role of arthropod saliva has been well documented, but evidence for an effect on Plasmodium sp. infectiousness remains controversial. Mosquito saliva may orient the immune response toward a Th2 profile, thereby priming a Th2 response against subsequent antigens, including Plasmodium. Orientation to...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.06414-11
更新日期:2012-06-01 00:00:00
abstract::Urogenital Chlamydia serovars replicating in reproductive epithelium pose a unique challenge to host immunity and vaccine development. Previous studies have shown that CD4 T cells are necessary and sufficient to clear primary Chlamydia muridarum genital tract infections in the mouse model, making a protective CD4 T ce...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.06339-11
更新日期:2012-06-01 00:00:00
abstract::Toxoplasma gondii infection in pregnant women may result in abortion or in fetal teratogenesis; however, the underlying mechanisms are still unclear. In this paper, based on a murine model, we showed that maternal infection with RH strain T. gondii tachyzoites induced elevated production of reactive oxygen species (RO...
journal_title:Infection and immunity
pub_type: 杂志文章,收录出版
doi:10.1128/IAI.06295-11
更新日期:2012-06-01 00:00:00
abstract::The adipocytokine leptin links nutritional status to immune function. Leptin signaling protects from amebiasis, but the molecular mechanism is not understood. We developed an in vitro model of ameba-host cell interaction to test the hypothesis that leptin prevents ameba-induced apoptosis in host epithelial cells. We d...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.06140-11
更新日期:2012-05-01 00:00:00
abstract::The ability of a pathogen to evade neutrophil phagocytic killing mechanisms is critically important for dissemination and establishment of a systemic infection. Understanding how pathogens overcome these innate defenses is essential for the development of optimal therapeutic strategies for invasive infections. CpsY is...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00027-12
更新日期:2012-05-01 00:00:00
abstract::Helicobacter pylori infection is thought to be involved in the development of several gastric diseases. Two H. pylori virulence factors (vacuolating cytotoxin A and cytotoxin-associated gene A) reportedly interact with lipid rafts in gastric epithelial cells. The role of Toll-like receptor (TLR)-mediated signaling in ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.05856-11
更新日期:2012-05-01 00:00:00
abstract::Plasmodium falciparum's ability to invade erythrocytes is essential for its survival within the human host. Immune mechanisms that impair this ability are therefore expected to contribute to immunity against the parasite. Plasma of humans who are naturally exposed to malaria has been shown to have growth-inhibitory ac...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.06190-11
更新日期:2012-05-01 00:00:00
abstract::Current efforts to develop plague vaccines focus on LcrV, a polypeptide that resides at the tip of type III secretion needles. LcrV-specific antibodies block Yersinia pestis type III injection of Yop effectors into host immune cells, thereby enabling phagocytes to kill the invading pathogen. Earlier work reported that...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.05637-11
更新日期:2012-04-01 00:00:00
abstract::D-Amino acid oxidase (DAO) is a hydrogen peroxide-generating enzyme that uses a D-amino acid as a substrate. We hypothesized that DAO may protect against bacterial infection, because hydrogen peroxide is one of the most important molecules in the antibacterial defense systems in mammals. We show here that DAO suppress...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.06214-11
更新日期:2012-04-01 00:00:00
abstract::Borrelia burgdorferi sensu stricto is the major causative agent of Lyme disease in the United States, while B. garinii and B. afzelii are more prevalent in Europe. The highly complex genome of B. burgdorferi is comprised of a linear chromosome and a large number of variably sized linear and circular plasmids. Many pla...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.06326-11
更新日期:2012-04-01 00:00:00